Acid resistant zirconium phosphate for the long term application of Ge-68/Ga-68 generator system

作者：Lee Jun Young; Vyas Chirag K; Kim Bo Ram; Kim Hee Jung; Hur Min Goo; Yang Seung Dae; Park Jeong Hoon^*; Kim Sang Wook^*

来源：Applied Radiation and Isotopes, 2016, 118: 343-349.

DOI：10.1016/j.apradiso.2016.09.025

• Zirconium phosphate
• Adsorbent
• Acid-resistance
• Radioisotope generator
• Ge-68/Ga-68

The Ge-68/Ga-68 generator system is an excellent source for producing ready-to-use Ga-68 in clinical Positron Emission Tomography (PET) applications. The column adsorbent is the key component for the 68Ge/68Ga generator system. Therefore, several studies have been conducted to identify column materials with a stable and superior elution yield in an acidic eluent (0.1 N HCl solution). In this study, four different zirconium phosphates were synthesized with a particle size of 200-800 nm, pore-size of 55190 A and surface area of 0.72-268 m(2) g(-1). Synthesized and studied amorphous zirconium phosphate (ZrP-1) exhibited excellent acid resistant properties for the 0.1 N HCl eluent and a large surface area of 268 m(2) g(-1). Amorphous ZrP-1 showed a good Ga-68 elution yield of 74% in 0.1 N HCl eluent accompanying extraordinary low breakthrough of Ge-68 (0.007%).

• 出版日期2016-12