Discrete-Time Signal Processing with DNA

作者：Jiang Hua; Salehi Sayed Ahmad; Riedel Marc D^*; Parhi Keshab K

来源：ACS Synthetic Biology, 2013, 2(5): 245-254.

DOI：10.1021/sb300087n

• signal processing
• molecular computing
• DNA computing
• DNA strand displacement
• sequential circuits
• recurrent circuits

We present a methodology for implementing discrete-time signal processing operations, such as filtering, with molecular reactions. The reactions produce time-varying output quantities of molecules as a function of time-varying input quantities according to a functional specification. This computation is robust and independent of the reaction rates, provided that the rate constants fall within coarse categories. We describe two approaches: one entails synchronization with a clock signal, implemented through sustained chemical oscillations; the other is self-timed or asynchronous. We illustrate the methodology by synthesizing a simple moving-average filter, a biquad filter, and a Fast Fourier Transform (FFT). Abstract molecular reactions for these filters and transforms are translated into DNA strand displacement reactions. The computation is validated through mass-action simulations of the DNA kinetics. Although a proof of concept for the time being, molecular filters and transforms have potential applications in fields such as biochemical sensing and drug delivery.

• 出版日期2013-5