Numerous Ontogenetic Roads to Mantle Cell Lymphoma Immunogenetic and Immunohistochemical Evidence

作者：Pouliou Evi; Xochelli Aliki; Kanellis George; Stalika Evangelia; Sutton Lesley Ann; Navarro Alba; Agathangelidis Andreas; Dimosthenous Kypros; Anagnostopoulos Achilles; Patsouris Efstratios; Korkolopoulou Penelope; Sundstrom Christer; Ghia Paolo; Ponzoni Maurilio; Sander Birgitta; Campo Elias; Rosenquist Richard; Hadzidimitriou Anastasia; Stamatopoulos Kostas; Papadaki Theodora

来源：American Journal Of Pathology, 2017, 187(7): 1454-1458.

DOI：10.1016/j.ajpath.2017.02.017

To obtain insight into the ontogeny of mantle cell lymphoma (MCL), we assessed 206 patients from a morphological, immunohistochemical, and immunogenetic perspective. Our series included nodal (n = 151), extranodal. (n = 28), and primary splenic (n = 27) MCL cases. Skewing of the immunoglobulin heavy variable (IGHV) gene repertoire was noted, with only four IGHV genes accounting for 46% of cases and approximately 70% of cases (107/154) bearing an imprint of somatic hypermutation (SHM) ranging from minimalto pronounced. Interestingly, a distinctive immunophenotypic and immunogenetic profile was identified for primary splenic MCL, which was enriched for DBA.44-positive cases (P < 0.001) and used the IGHV1-8 gene more frequently (P = 0.02) compared to nodal or extranodal cases, alluding to distinct immunopathogenetic and antigen selection processes. Expression of CD27 (considered a marker of activated B cells) was generally dissociated from SHM and was more prevalent in cases with no or minimal/borderline SHM. These findings support the idea that antigen drive is relevant for most MCL cases, although the specific antigens and the precise location of affinity maturation remain to be elucidated. Moreover, they raise the intriguing hypothesis of multiple cellular origins for MCL.

• 出版日期2017-7