Abnormal Tr1 differentiation in multiple sclerosis

作者：Astier Ame L^*; Hafler David A

来源：Journal of Neuroimmunology, 2007, 191(1-2): 70-78.

DOI：10.1016/j.jneuroim.2007.09.018

• multiple sclerosis
• Tr1 regulatory T cells
• IL-10
• CD46

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). In the recent years, accumulating evidence has supported an immunosuppressive role for regulatory T cells (Tregs). Most studies in the context of autoimmunity have focused on the defects of the CD4(+)CD25(high) Tregs. However, we recently demonstrated an altered function of Tr1 Treg cells in MS, characterized by a lack of IL-10 secretion. Therefore, several major regulatory T cell defects are involved in human autoimmune disease. Hence, the induction of Tregs or the stimulation of Treg activity may be beneficial for the treatment of such diseases.

• 出版日期2007-11