An Overview of Molecular Profiles in Ulcerative Colitis-Related Cancer

作者：Xue, Meng; Shi, Liuhong; Wang, Weijia; Chen, Shujie; Wang, Liangjing^*

来源：Inflammatory Bowel Diseases, 2018, 24(9): 1883-1894.

DOI：10.1093/ibd/izy221

• ulcerative colitis
• colorectal cancer
• genetics
• epigenetics
• molecule
• gut microbiota

Ulcerative colitis (UC) is an independent risk factor of colorectal cancer (CRC). Both genetic and epigentic events induce a unique molecular profile during the development from UC to UC-related CRC (UCRC). These molecular changes play varied roles in DNA repair, immune response, cell metabolism, and interaction with the microbiota during the carcinogenesis process. This review will systmatically discuss the molecular characteristics of UCRC and point out the future perspectives in this research field.

• 出版日期2018-9
• 单位浙江大学