Anti-diabetic activity in type 2 diabetic mice and alpha-glucosidase inhibitory, antioxidant and anti-inflammatory potential of chemically profiled pear peel and pulp extracts (Pyrus spp.)

作者：Wang Tingting; Li Xia^*; Zhou Bin; Li Hongfa; Zeng Jie; Gao Wenyuan

来源：Journal of Functional Foods, 2015, 13: 276-288.

DOI：10.1016/j.jff.2014.12.049

• Pear peel
• Anti-diabetic
• Antioxidant
• Anti-inflammatory
• alpha-glucosidase
• Type 2 diabetes

Total phenolic acids, total flavonoids, total triterpenes contents, and eleven monomeric compounds, derived from eight different pears' peel and pulp, were qualitatively and quantitively profiled utilizing HPLC and HPLC-MS. All the chemical components found in the peel were approximately 2 to 18 folds concentrated than those in the pulp. Their antioxidant (reducing power and 2, 2-diphenyl-1-picrylhydrazyl/DPPH assay) and anti-inflammatory (xyleneinduced mouse ear edema assay) activities were comparatively evaluated. Correlation analysis and principal component analysis were utilized to seek bioactive components in antioxidant and anti-inflammatory activities. Subsequently, Yaguang pear (Pyrus ussuriensis Maxim, with high polyphenols content) was selected to investigate in vitro and in vivo anti-diabetic potential (alpha-glucosidase inhibition assay and hypoglycemic assay in streptozocin-induced type 2 diabetic mice). Eleven monomeric compounds were seriatim examined for a-glucosidase inhibitory activity to fish out anti-diabetic components. For the first time, this study delineated pear peel's anti-diabetic prospect of treatment for type 2 diabetes.

• 出版日期2015-3
• 单位天津大学