A Direct C-H/Ar-H Coupling Approach to Oxindoles, Thio-oxindoles, 3,4-Dihydro-1H-quinolin-2-ones, and 1,2,3,4-Tetrahydroquinolines

作者：Hurst Timothy E; Gorman Ryan M; Drouhin Pauline; Perry Alexis; Taylor Richard J K^*

来源：Chemistry - A European Journal, 2014, 20(43): 14063-14073.

DOI：10.1002/chem.201403917

• dihydroquinolinones
• catalysis
• copper
• oxindoles
• tetrahydroquinolines

A copper(II)-catalysed approach to oxindoles, thio-oxindoles, 3,4-dihydro-1H-quinolin-2-ones, and 1,2,3,4-tetrahydroquinolines via formal C-H, Ar-H coupling is described. In a new variant, copper(II) 2-ethylhexanoate has been identified as an inexpensive and efficient catalyst for this transformation, which utilises atmospheric oxygen as the re-oxidant.

• 出版日期2014-10-20