Apparent diffusion coefficient reduction might be a predictor of poor outcome in patients with posterior reversible encephalopathy syndrome

作者：Ninomiya Itaru; Kanazawa Masato^*; Akaiwa Yasuhisa; Shimohata Takayoshi; Okamoto Kouichirou; Onodera Osamu; Nishizawa Masatoyo

来源：Journal of the Neurological Sciences, 2017, 381: 1-3.

DOI：10.1016/j.jns.2017.08.002

• Posterior reversible encephalopathy syndrome
• Apparent diffusion coefficient map
• MRI
• Outcome

It is thought that posterior reversible encephalopathy syndrome (PRES) is both clinically and radiologically reversible. However, its reversible nature has been challenged based on reports of permanent neurological impairments. The factors that predict the development of irreversible neurological impairment are still unclear. In the present study, we investigated clinical manifestations, laboratory findings, and neuroradiological images to identify predictors of functional outcomes in PRES. We investigated 23 PRES patients. Apparent diffusion coefficient (ADC) reduction was observed in 4 patients in the poor outcome group, whereas no patients presented ADC reduction in the favourable outcome group (p < 0.01). Further studies are warranted to evaluate the association between ADC reduction and functional outcome after PRES.

• 出版日期2017-10-15