Effect of sumatriptan on gastric emptying: A crossover study using the BreathID system

作者：Sakamoto Yasunari; Sekino Yusuke; Yamada Eiji; Higurashi Takuma; Ohkubo Hidenori; Sakai Eiji; Endo Hiroki; Iida Hiroshi; Nonaka Takashi; Fujita Koji; Yoneda Masato; Koide Tomoko; Takahashi Hirokazu; Goto Ayumu; Abe Yasunobu; Gotoh Eiji; Maeda Shin; Nakajima Atsushi; Inamori Masahiko^*

来源：World Journal of Gastroenterology, 2012, 18(26): 3415-3419.

DOI：10.3748/wjg.v18.i26.3415

• Sumatriptan
• Gastric emptying
• Breath test
• Liquid meal
• BreathID system

AIM: TO determine the effect of oral sumatriptan on gastric emptying using a continuous C-13 breath test (BreathID system). %26lt;br%26gt;METHODS: Ten healthy male volunteers participated in this randomized, 2-way crossover study. The subjects fasted overnight and were randomly assigned to receive a test meal (200 kcal/200 mL) 30 min after pre-medication with sumatriptan 50 mg (sumatriptan condition), or the test meal alone (control condition). Gastric emptying was monitored for 4 h after administration of the test meal by the C-13-acetic acid breath test performed continually using the BreathID system. Then, using Oridion Research Software (beta version), the time taken for emptying of 50% of the labeled meal (T-1/2) similar to the scintigraphy lag time for 10% emptying of the labeled meal (T-lag), the gastric emptying coefficient (GEC), and the regression-estimated constants (beta and kappa) were calculated. The statistical significance of any differences in the parameters were analyzed using Wilcoxon%26apos;s signed-rank test. %26lt;br%26gt;RESULTS: In the sumatriptan condition, significant differences compared with the control condition were found in T-1/2 [median 131.84 min (range, 103.13-168.70) vs 120.27 min (89.61-138.25); P = 0.0016], T-lag [median 80.085 min (59.23-125.89) vs 61.11 min (39.86-87.05); P = 0.0125], and beta [median 2.3374 (1.6407-3.8209) vs 2.0847 (1.4755-2.9269); P = 0.0284]. There were no significant differences in the GEC or kappa between the 2 conditions. %26lt;br%26gt;CONCLUSION: This study showed that oral sumatriptan significantly delayed gastric emptying of a liquid meal.

• 出版日期2012-6-14