The meaning of mitochondrial movement to a neuron's life

作者：Lovas Jonathan R; Wang Xinnan^*

来源：Biochimica et Biophysica Acta-Molecular Cell Research, 2013, 1833(1): 184-194.

DOI：10.1016/j.bbamcr.2012.04.007

• Mitochondrial movement
• Neuron
• Neurodegeneration
• Ca plus
• Parkinson's
• Mitophagy

Cells precisely regulate mitochondrial movement in order to balance energy needs and avoid cell death. Neurons are particularly susceptible to disturbance of mitochondrial motility and distribution due to their highly extended structures and specialized function. Regulation of mitochondrial motility plays a vital role in neuronal health and death. Here we review the current understanding of regulatory mechanisms that govern neuronal mitochondrial transport and probe their implication in health and disease. This article is part of a Special Issue entitled: Mitochondrial dynamics and physiology. Published by Elsevier B.V.

• 出版日期2013-1