Detection of a Transient R292K Mutation in Influenza A/H3N2 Viruses Shed for Several Weeks by an Immunocompromised Patient

作者：Babady N Esther^*; Laplante Jennifer M; Tang Yi Wei; St George Kirsten

来源：Journal of Clinical Microbiology, 2015, 53(4): 1415-1418.

DOI：10.1128/JCM.02845-14

We describe the case of an immunocompromised patient, positive for influenza A virus (H3N2), in whom the neuraminidase R292K mutation was transiently detected during oseltamivir treatment. The R292K mutation was identified by direct testing in 3 of 11 respiratory specimens collected throughout the patient's illness but in none of the cultures from those specimens.

• 出版日期2015-4