Hepatitis From Spiroplasma sp in an Immunocompromised Patient

作者：Mueller N J^*; Tini G M; Weber A; Gaspert A; Husmann L; Bloemberg G; Boehler A; Benden C

来源：American Journal of Transplantation, 2015, 15(9): 2511-2516.

DOI：10.1111/ajt.13254

• clinical research
• practice
• infectious disease
• lung transplantation
• pulmonology
• infection and infectious agents
• bacterial
• antibiotic: antibacterial

A 70-year-old lung transplant recipient patient was admitted with fever, nausea, abdominal pain, peripheral edema and pronounced weakness. An initial work-up for presumed infection revealed cholestatic hepatitis, leukocytosis and thrombocytopenia, but failed to detect a pathogen. An increased glucose uptake exclusively in the liver was demonstrated by positron emission tomography. Liver biopsy showed basophilic inclusions in the cytoplasm of hepatocytes. Broad-range 16S rRNA gene PCR followed by sequence analysis yielded Spiroplasma sp. in two independent blood samples and the liver biopsy, confirming Spiroplasma sp. as the causative agent. Antibiotic treatment with doxycycline and azithromycin led to complete recovery.

• 出版日期2015-9
• 单位河北医科大学