A unique complex translocation involving six different chromosomes in a case of childhood acute lymphoblastic leukemia with the Philadelphia chromosome and adverse prognosis

作者：Al Achkar Walid^*; Wafa Abdulsamad; Mkrtchyan Hasmik; Moassass Faten; Liehr Thomas

来源：Oncology Letters, 2010, 1(5): 801-804.

DOI：10.3892/ol_00000140

• childhood B-cell acute lymphoblastic leukemia
• BCR/ABL positive
• chromosomal aberrations
• fluorescence in situ hybridization
• multicolor banding

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Approximately 84% of cases of ALL are classified as B-precursor ALL, 14% of cases are T-cell and 2% of cases are B-cell (B-)ALL. About one third of B-ALL cases show an abnormal karyotype. Combining data obtained by immunophenotyping, karyotyping and molecular cytogenetic analyses allows for a better understanding of this heterogeneous disease. This study reports an exceptional B-ALL case with a poor prognosis and unique complex chromosomal aberrations not previously observed, i.e., a translocation involving the six chromosomal regions 1q42, 4q21, 4q24, 4q35 (twice), 8q22 and 10p15.3 besides 9q34 and 22g11.2.

• 出版日期2010-10