An unusual manifestation of post-transplant lymphoproliferative disorder in the lip after pediatric heart transplantation

作者：Chen C; Akanay Diesel S; Schuster F R; Klee D; Schmidt K G; Donner B C^*

来源：Pediatric Transplantation, 2012, 16(7): E320-E324.

DOI：10.1111/j.1399-3046.2012.01673.x

• post-transplant lymphoproliferative disorder
• pediatric heart transplantation
• immunosuppression
• Epstein-Barr virus
• rituximab

Chen C, Akanay-Diesel S, Schuster FR, Klee D, Schmidt KG, Donner BC. An unusual manifestation of post-transplant lymphoproliferative disorder in the lip after pediatric heart transplantation. ?Pediatr Transplantation 2012. (c) 2012 John Wiley %26 Sons A/S. Abstract: PTLD is a serious and frequently observed complication after solid organ transplantation. We present a six-yr-old girl with a rapidly growing, solid tumor of the lip four yr after orthotopic heart transplantation, which was classified as monomorphic PTLD with the characteristics of a diffuse large B-cell lymphoma. Treatment with reduction in immunosuppression, ganciclovir, and anti B-cell monoclonal antibody (rituximab) resulted in full remission since 12 months. To the best of our knowledge, this report is the first description of PTLD in the lip in a pediatric patient after heart transplantation in the English literature.

• 出版日期2012-11