A Polysaccharide from Ganoderma atrum Improves Liver Function in Type 2 Diabetic Rats via Antioxidant Action and Short-Chain Fatty Acids Excretion

作者：Zhu, Ke-Xue; Nie, Shao-Ping^*; Tang, Le-He; Li, Chuan; Gong, De-Ming; Xie, Ming-Yong

来源：Journal of Agricultural and Food Chemistry, 2016, 64(9): 1938-1944.

DOI：10.1021/acs.jafc.5b06103

• polysaccharide
• Ganoderma atrum
• type 2 diabetes
• liver function
• short-chain fatty acids

The present study was to evaluate the beneficial effect of polysaccharide isolated from Ganoderma atrum (PSG-1) on liver function in type 2 diabetic rats. Results showed that PSG-1 decreased the activities of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), while increasing hepatic glycogen levels. PSG-1 also exerted strong antioxidant activities, together with upregulated mRNA expression of peroxisome proliferator-activated receptor-gamma (PPAR-gamma), glucose transporter-4 (GLUT4), phosphoinositide 3-kinase (PI3K), and phosphorylated-Akt (p-Akt) in the liver of diabetic rats. Moreover, the concentrations of short-chain fatty acids (SCFA) were significantly higher in the liver, serum, and faeces of diabetic rats after treating with PSG-1 for 4 weeks. These results suggest that the improvement of PSG-1 on liver function in type 2 diabetic rats may be due to its antioxidant effects, SCFA excretion in the colon from PSG-1, and regulation of hepatic glucose uptake by inducing GLUT4 translocation through PI3K/Akt signaling pathways.

• 出版日期2016-3-9
• 单位中国热带农业科学院; 南昌大学; 食品科学与技术国家重点实验室; 海南大学