Pulsed Electromagnetic Field with Temozolomide Can Elicit an Epigenetic Pro-apoptotic Effect on Glioblastoma T98G Cells

作者：Pasi Francesca; Fassina Lorenzo; Mognaschi Maria Evelina; Lupo Giuseppe; Corbella Franco; Nano Rosanna^*; Capelli Enrica^*

来源：Anticancer Research, 2016, 36(11): 5821-5826.

DOI：10.21873/anticanres.11166

• Glioblastoma multiforme
• temozolomide
• pulsed electromagnetic stimulation
• epigenetic pro-apoptotic effect

Treatment with pulsed electromagnetic fields (PEMFs) is emerging as an interesting therapeutic option for patients with cancer. The literature has demonstrated that low-frequency/low-energy electromagnetic fields do not cause predictable effects on DNA; however, they can epigenetically act on gene expression. The aim of the present work was to study a possible epigenetic effect of a PEMF, mediated by miRNAs, on a human glioblastoma cell line (T98G). We tested a PEMF (maximum magnetic induction, 2 mT; frequency, 75 Hz) that has been demonstrated to induce autophagy in glioblastoma cells. In particular, we studied the effect of PEMF on the expression of genes involved in cancer progression and a promising synergistic effect with temozolomide, a frequently used drug to treat glioblastoma multiforme. We found that electromagnetic stimulation in combination with temozolomide can elicit an epigenetic pro-apoptotic effect in the chemo-and radioresistant T98G glioblastoma cell line.

• 出版日期2016-11