Sterols from the Stems of Momordica charantia

作者：Liao Yun Wen; Chen Chiy Rong; Hsu Jue Liang; Cheng Hsueh Ling; Shih Wen Ling; Kuo Yueh Hsiung; Huang Tzou Chi^*; Chang Chi I

来源：Journal of the Chinese Chemical Society, 2011, 58(7): 893-898.

• Momordica charantia
• Cucurbitaceae
• Stem
• Sterol
• Ergostane

A new sterol, 5 alpha,6 alpha-epoxy-3 beta-hydroxy-(22E,24R)-ergosta-8,22-dien-7-one (1), together with eight known sterols, 5 alpha,6 alpha-epoxy-(22E,24R)-ergosta-8,22-diene-3 beta,7 alpha-diol (2), 5 alpha,6 alpha-epoxy-(22E,24R)-ergosta-8,22-diene-3 beta,7 beta-diol (3), 5 alpha,6 alpha-epoxy-(22E,24R)-ergosta-8(14),22-diene-3 beta,7 alpha-diol (4), 3 beta-hydroxy-(22E,24R)-ergosta-5,8,22-trien-7-one (5), ergosterol peroxide (6), clerosterol (7), decortinol (8), and decortinone (9), were isolated from the stems of Momordica charantia. Their structures were elucidated by mean of extensive spectroscopic methods, including H-1, C-13, 2D-NMR and HR-EI-MS, as well as comparison with the literature data. Compounds 1, 4, 5, 8, and 9 were not cytotoxic against the SK-Hep 1 cell line.

• 出版日期2011-12
• 单位中国医科大学