A Short-Term Scan-Rescan Reliability Test Measuring Brain Tissue and Subcortical Hyperintensity Volumetrics Obtained Using the Lesion Explorer Structural MRI Processing Pipeline

作者：Ramirez Joel^*; Scott Christopher J M; Black Sandra E

来源：Brain Topography, 2013, 26(1): 35-38.

DOI：10.1007/s10548-012-0228-z

• MRI
• Progression
• Aging
• Alzheimer disease
• White matter hyperintensities
• Leukoariosis
• Segmentation
• Tissue segmentation reliability
• Atrophy

Lesion Explorer (LE) is a reliable and comprehensive MRI-derived tissue segmentation and brain region parcellation processing pipeline for obtaining intracranial tissue and subcortical hyperintensity (SH) volumetrics. The processing pipeline segments: gray (GM) and white matter (WM); sulcal (sCSF) and ventricular cerebrospinal fluid (vCSF); periventricular (pvSH) and deep white subcortical hyperintensities (dwSH); and cystic fluid filled lacunar-like infarcts (Lacunar); into 26 regions of interest. A short-term scan-rescan reliability test was performed on 20 healthy volunteers: 10 older (mean = 77.7 years, SD = 11.1) and 10 younger (mean = 29.4 years, SD = 7.1). Each participant was scanned twice with an average interscan interval of 15.4 days (range: 29 min-50 days). Results suggest low technique-related error as indicated by excellent intraclass correlation coefficient (ICC) results, with ICCs above 0.90 (p < 0.05) for GM, WM, and CSF, in all 26 regions of interest (13 per hemisphere). Ventricular and lesion sub-type (pvSH, dwSH, and Lacunar) volumes also showed high scan-rescan reliability (dwSH = 0.9998, pvSH = 0.9998, Lacunar = 0.9859, p < 0.01). As indicated by the results of this short-term scan-rescan study, the LE structural MRI processing pipeline can be applied for longitudinal volumetric analyses with confidence.

• 出版日期2013-1
• 单位河北医科大学