A novel biocompatible drug carrier for oral delivery and controlled release of antibiotic drug: loading and release of clarithromycin as an antibiotic drug model

作者：Moazzen Elahe; Ebrahimzadeh Homeira; Amini Mostafa M^*; Sadeghi Omid

来源：Journal of Sol-Gel Science and Technology, 2013, 66(2): 345-351.

DOI：10.1007/s10971-013-3016-7

• Drug delivery
• Controlled-release
• Nanoporous carbon
• Clarithromycin
• Amine functionalized

In this work, a novel biocompatible carrier was designed by modification of nanoporous carbon material and synthesized by hydrothermal condensation of d-Fructose, as the carbon source, in the presence of Pluronic(A (R)) F127, as the surfactant. The prepared material is completely biocompatible and suitable for oral drug delivery. As this nanoporous carbon has surface decorated hydroxyl groups, they are able to react with 3-aminopropyltriethoxysilane agent and produce amino-functionalized nanoporous carbon. The synthesis of amine-modified carbon nanoporous material was confirmed by X-ray powder diffraction, IR spectroscopy, elemental analysis, thermal analysis and nitrogen adsorption analysis. Clarithromycin as an active drug molecule with carbonyl and hydroxyl functional groups in chemical structure was chosen as the drug model and stored in pores of the amine-modified nanoporous carbon. Release of clarithromycin from modified nanoporous carbon was investigated in mouth and stomach pH values. The results showed that this drug carrier can transfer the drug up to stomach without any leak or release. The release time was investigated, and the results showed that the carrier is also successful for the controlled-release delivery.

• 出版日期2013-5