Does Oral Clonidine Premedication Decrease Bleeding During Open Rhinoplasty?

作者：Tabrizi Reza^*; Eftekharian Hamidreza; Pourdanesh Freydoun; Khaghaninejad Mohammad Saleh

来源：Journal of Craniofacial Surgery, 2014, 25(3): 1101-1103.

DOI：10.1097/SCS.0000000000000660

• Clonidine
• blood loss
• rhinoplasty
• premedication

This uni-blind randomized clinical trial study investigated the effect of clonidine premedication on preoperative blood loss during open rhinoplasty. The subjects were randomly divided into 2 groups. The members of the first group received oral clonidine as a single dose (0.2 mg) 2 hours before the induction of general anesthesia, whereas the members of the second group received a placebo. All subjects underwent open rhinoplasty without septoplasty. One anesthetic protocol was followed for all subjects. Variable factors include the subjects%26apos; weight, age, sex, and blood pressure during the surgery as well as blood loss during rhinoplasty. Group 1 consisted of 22 women and 11 men, whereas group 2 was composed of 16 women and 17 men. The mean for blood loss amounted to 68.03 +/- 22.49 mL for group 1 and 132.12 +/- 78.53 mL for group 2. An assessment demonstrated a significant difference in blood loss between the 2 groups (P %26lt; 0.001.) Oral clonidine premedication thus may decrease preoperative bleeding during open rhinoplasty.

• 出版日期2014-5