An innovative synthesis of tertiary hydroxyl thieno[2,3-d]pyrimidinone skeleton: natural-like product from the tandem reaction of o-aminothienonitrile and carbonyl compound

作者：Yang, Junjuan; Shi, Daxin; Hao, Pengfei; Yang, Deli; Zhang, Qi; Li, Jiarong^*

来源：Tetrahedron Letters, 2016, 57(22): 2455-2461.

DOI：10.1016/j.tetlet.2016.04.088

• Tertiary hydroxylated thieno[2,3-d]pyrimidinone
• o-Aminothienonitrile
• Carbonyl compound
• Photo-catalytic oxygenation
• PDF conversion

A straightforward base accelerant tandem protocol for the synthesis of the tertiary hydroxyl natural-like thieno[2,3-d]pyrimidinone skeleton was developed from the cyclocondensation of o-aminothienonitrile and carbonyl compound. The reaction process includes PDF conversion and photo-catalytic oxygenation. This synthetic strategy offers an alternative method for regioselective construction of tertiary hydroxylated thieno[2,3-d]pyrimidinone architectures with kinetic, thermodynamic control, and six-member ring effect.

• 出版日期2016-6-1
• 单位山西师范大学; 北京理工大学