Anaplasma phagocytophilum and Ehrlichia chaffeensis type IV secretion and Ank proteins

作者：Rikihisa Yasuko^*; Lin Mingqun

来源：Current Opinion in Microbiology, 2010, 13(1): 59-66.

DOI：10.1016/j.mib.2009.12.008

The obligatory intracellular bacterial pathogens Anaplasma and Ehrlichia infect leukocytes by hijacking host-cell components and processes. The type IV secretion system is up-regulated during infection. Among type IV secretion candidate substrates, an ankyrin repeat protein of Anaplasma phagocytophilum, AnkA, is delivered into the host cytoplasm via a complex that includes VirD4. AnkA is highly tyrosine phosphorylated and binds to the AbI interactor 1, SHP-1, and nuclear DNA fragments. Ehrlichia chaffeensis AnkA was recently reported to be translocated into host-cell nucleus. The recent discovery of several ankyrin repeat proteins secreted via the type IV secretion system of different intracellular bacteria suggests that a common strategy evolved to subvert host-cell functions.

• 出版日期2010-2