科研之友
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摘要
Background: Other than the in vitro erythrocyte hemolysis test, no valid biomarkers of vitamin E status currently exist. %26lt;br%26gt;Objective: We hypothesized that the urinary vitamin E metabolite alpha-carboxyethyl hydroxychroman (alpha-CEHC) could serve as a biomarker. %26lt;br%26gt;Design: The relations between urinary alpha-CEHC, plasma alpha-tocopherol, and vitamin E intakes were assessed by using a previously validated multipass, Web-based, 24-h self-administered dietary recall, and we concurrently collected plasma and 24-h urine samples from 233 participants of both sexes. %26lt;br%26gt;Results: Median vitamin E intakes were 9.7 mg alpha-tocopherol/d. Intakes were correlated with plasma alpha-tocopherol (R = 0.40, P %26lt; 0.001) and urinary alpha-CEHC (R = 0.42, P %26lt; 0.001); these correlations were essentially unchanged after multivariate adjustments. On the basis of multiple regression analysis, urinary alpha-CEHC excretion increased by similar to 0.086 mu mol/g creatinine (95% CI: 0.047, 0.125) for every 1-mg (2.3-mu mol) increase in dietary alpha-tocopherol. Urinary alpha-CEHC excretion remained at a plateau (median: 1.39 mu mol/g creatinine) until dietary intakes of alpha-tocopherol exceeded 9 mg alpha-tocopherol/d. The inflection point at which vitamin E metabolism increased was estimated to be at an intake of 12.8 mg alpha-tocopherol/d. Daily excretion of %26gt;1.39 mu mol alpha-CEHC/g creatinine is associated with a greater than adequate alpha-tocopherol status, as evidenced by increased vitamin E metabolism and excretion. %26lt;br%26gt;Conclusion: Thus, urinary alpha-CEHC is a valid biomarker of alpha-tocopherol status that can be used to set a value for the Estimated Adequate Requirement of vitamin E. Am J Clin Nutr 2012;96:801-9.
- 出版日期2012-10
