A star-shaped molecularly imprinted polymer derived from polyhedral oligomeric silsesquioxanes with improved site accessibility and capacity for enantiomeric separation via capillary electrochromatography

作者：Song, Wen-Fang; Zhao, Qing-Li; Zhou, Xiu-Jie; Zhang, Li-Shun; Huang, Yan-Ping^*; Liu, Zhao-Sheng^*

来源：Microchimica Acta, 2019, 186(1): 22.

DOI：10.1007/s00604-018-3151-5

• Star-shaped polymers
• Ov-POSS
• Molecular recognition
• Low cross-linking
• Dendrimers
• S-Amlodipine
• Chiral separation
• Capillary coating
• Imprinting effect

A star-shaped molecularly imprinted coating was prepared starting from octavinyl-modified polyhedral oligomeric silsesquioxanes (Ov-POSS). It possesses a relatively open structure and has good site accessibility and a larger capacity even at lower cross-linking. The imprinted coating was prepared from S-amlodipine (S-AML) as the template and analyte, Ov-POSS as the cross-linker, and methacrylic acid as the functional monomer. The preparation and chromatographic parameters were optimized, including ratio of template to functional monomer, apparent cross-linking degree, pH value, ACN content and salt concentration in the mobile phase. The best resolution in enantiomer separation by means of capillary electrochromatography reaches a value of 33. A good recognition ability (=2.60) was obtained and the column efficiency for S-AML was 54,000 plates m(-1). The use of Ov-POSS as a cross-linker significantly improves the column capacity and thus the detection sensitivity. The results show that Ov-POSS is an effective cross-linker for thepreparation of imprinted polymers with good accessibility and large capacity.

• 出版日期2019-1
• 单位天津医科大学