科研之友
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摘要
The metastatic process comprises several steps all dependent on different factors: cell proliferation and the Raf-MEK-ERK pathway, initiation, migration and angiogenesis via VEGF and collagenases (which digest the extracellular matrix), metastatic progression in bloodstream and implantation in a target tissues via CXCR4 according to the gradient of SDF1 chemokine. At present, inhibition of VEGF by antiangiogenic the treatment results in the activation of alternative pathways and recovery of metastasis process. The future of targeted therapies will integrate alternative paths, including CXCR4/SDF1 ones.
- 出版日期2011-3
