科研之友
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摘要
Objective: The aim of this randomized, double-blind, placebo-controlled clinical trial was to evaluate the effect of dydrogesterone and calcium plus vitamin D on young women's general health Method: One hundred and eighty students studying at Shiraz University were recruited Students completed the General Health Questionnaires (GHQ-28) prior to participation They were then randomly assigned to take a tablet contaimng either 5 mg of dydrogesterone, 500 mg of calcium plus 200 mg of vitamin D, or a placebo twice daily from the 15th to the 24th day of their menstrual cycle for 2 consecutive cycles, and to complete the same questionnaires during both the intervention cycles Results: The effects of dydrogesterone and calcium plus vitamin D on general health scores were similar during the first month of intervention (11 41 4 28, 12 23 3 76, respectively) (p>0 05) and both of them were more effective than placebo (16 69 3 28) (p<0 05) However, dydrogesterone was more effective than calcium plus vitamin D and placebo during the second month of intervention (433 2 69, 62 3 55, 1439 3 45, respectively) (p<0 05) No significant differences between groups regarding drugs' side effects (p>0 05) were found Conclusion: Both dydrogesterone and calcium D were more effective than placebo in promoting women's general health Dydrogesterone was, however, more efficient than calcium plus vitamin D
- 出版日期2010-7
