Adiponectin profiles are affected by chronic and acute changes in carbohydrate intake in healthy cats

作者：Tan Heok Yit; Rand Jacquie S^*; Morton John M; Fleeman Linda M; Armstrong P Jane; Coradini Marcia; Ishioka Katsumi; Verkest Kurt R; Richards Ayanthi A; Rawlings John M; Rose Felicity J; Whitehead Jonathan P

来源：General and Comparative Endocrinology, 2011, 172(3): 468-474.

DOI：10.1016/j.ygcen.2011.04.012

• Adipokine
• Diet
• Fasting
• Postprandial

Adiponectin is a key adipokine that regulates carbohydrate and lipid metabolism. It circulates in stable low (LMW) and high molecular weight (HMW) forms. The aims of this study were to characterize baseline adiponectin profiles (total, LMW and HMW multimers) in healthy cats and to assess the effects of varying dietary carbohydrate content on adiponectin profiles. Cats were maintained on a diet with moderate carbohydrate content (37% metabolisable energy [ME]) for 4 weeks and then randomly allocated to either a low carbohydrate (19% ME) or high carbohydrate (52% ME) diet for 4 weeks. Fasting and postprandial plasma adiponectin profiles were measured by ELISA and sucrose gradient/Western blot. After consuming the moderate carbohydrate diet for 4 weeks, fasting total, HMW and LMW plasma adiponectin concentrations were 5.0 +/- 0.6, 2.5 +/- 0.5 and 2.6 +/- 0.2 mu g/mL, respectively. After changing to the low carbohydrate diet, fasting total adiponectin was unchanged but HMW adiponectin increased and LMW adiponectin decreased. No significant postprandial changes were observed. Cats consuming the high carbohydrate diet had increased fasting total and LMW adiponectin with no change in HMW adiponectin. In the postprandial state total adiponectin was reduced and there was a trend towards a decrease in HMW (p = 0.086) but not LMW multimers. These data indicate that feline adiponectin multimer profiles are similar to those reported in other species and demonstrate that changes in plasma adiponectin occur in response to chronic and acute carbohydrate intake and these reflect differential changes in adiponectin multimers.

• 出版日期2011-7-1