Does Assisted Reproductive Technology Itself or Polycystic Ovary Syndrome as a Cause of Infertility Have Any Effect on First Trimester Serum Screening Results?

作者：Kosus Aydin; Kosus Nermin^*; Duran Muzeyyen; Turhan Nilgun O

来源：Journal of Reproductive Medicine, 2012, 57(3-4): 129-135.

• assisted reproductive techniques
• crown-rump length
• first trimester screening
• HCG-beta
• infertility
• nuchal translucency measurement
• PAPP-A
• polycystic ovary syndrome
• prenatal ultrasonography
• reproductive technology, assisted

OBJECTIVE: To determine whether assisted reproductive technology (ART) itself or polycystic ovary syndrome (PCOS) as a cause of infertility has any effect on first trimester serum screening results.
STUDY DESIGN: First trimester serum. screening results of ART pregnancies of women with PCOS (IVF-P group) were compared with those of women who underwent ART due to male factor infertility (IVF-H group) and women who conceived spontaneously.
RESULTS: Comparison of the groups for crown-rump length (CRL) and nuchal translucency revealed no significance. There was significant difference between the IVF-H and IVF-P groups in terms of free beta-human chorionic gonadotropin (beta-hCG) levels. Although comparison of groups revealed no significance, pregnancy-associated plasma protein A (PAPP-A) values were higher in the IVF-P group than in the group.
CONCLUSION: CRL and nuchal translucency measurements were not affected by in vitro fertilization procedures or the presence of maternal PCOS. Use of ART decreased PAPP-A and increased free beta-hCG levels. Although not significant, PAPP-A was higher in PCOS patients who conceived with ART, which may in turn increase false negative rates in these cases. (J Reprod Med 2012;57:129-135)

• 出版日期2012-4