Determination of the absolute configuration and identity of chiral carboxylic acids using a Cu(II) complex of pyridine-benzimidazole-based ligand

作者：Zhao Shuang; Ito Shintaro; Ohba Yoshihiro; Katagiri Hiroshi^*

来源：Tetrahedron Letters, 2014, 55(13): 2097-2100.

DOI：10.1016/j.tetlet.2014.02.032

• Circular dichroism
• Chirality
• Molecular recognition
• Identity
• Carboxylic acid

We report a new achiral Cu host [Cu(bmb-bpy)(H2O)(OTf)(2)] (bmb-bpy 6,6%26apos;-bis[((1-meth-ylbenzimidazol-2-yl)thio)methyl]-2,2%26apos;-bipyridine) for the enantioselective and chemoselective recognition of chiral carboxylic acids. The binding of chiral carboxylic acids to [Cu(bmb-bpy)(H2O)(OTf)(2)] produced an exciton-coupled circular dichroism signal; the linear discriminant analysis allowed the assignment of the absolute configuration, enantiomeric excess, and identity of chiral carboxylic acids.

• 出版日期2014-3-26