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摘要
Background and Aims Sepsis is an important complication and cause of morbidity and mortality in acute pancreatitis (AP). The source of sepsis may be infected pancreatic and peripancreatic collections and/or necrosis or extrapancreatic including infections in the bloodstream or respiratory and urinary tracts. We studied the implications of the source of sepsis on various outcome parameters in AP like persistent organ failure (POF), length of hospital (LOH) stay, and mortality. Methods A retrospective analysis of culture reports of AP patients was done, and the outcome parameters were recorded. Results Three hundred fifty-seven patients (229M; age: 40.3 +/- 14.04 years) of AP who had detailed culture reports were included. Eighty-four (23.5%) patients had pancreatic (or peripancreatic) source (group 1), 52 (14.6%) patients had other (extrapancreatic) sources (group 2), 20 (5.6%) patients were noted to have positive cultures from sources, which were both pancreatic and extrapancreatic (combined) sources (group 3), while 201 patients had sterile cultures. POF was seen in 147 (48%) patients (group 1: 67.8%; group 2: 65%; group 3: 90%; group 4: 34% [P<0.001]). The mean LOH stay was 22.1 +/- 20.26 days (group 1: 30.2 +/- 20.64 days; group 2: 26.4 +/- 26.82 days; group 3: 47.3 +/- 32.60 days; group 4: 15.2 +/- 11.34 days [P<0.001]). Seventy (19.7%) patients succumbed to their illness (group 1 [22.9%]; group 2 [36.5%]; group 3 [40%]; group 4 [12%] [P<0.001]). Conclusions POF and LOH stay were more common in patients with combined pancreatic and extrapancreatic sources of sepsis. Mortality was significantly higher in patients with sepsis (groups 1, 2, 3) compared with sterile groups.
- 出版日期2013-5
- 单位河北医科大学
