Microvascular complications and prevalence of urgency incontinence in Japanese patients with type 2 diabetes mellitus: The dogo study

作者：Furukawa Shinya^*; Sakai Takenori; Niiya Tetsuji; Miyaoka Hiroaki; Miyake Teruki; Yamamoto Shin; Maruyama Koutatsu; Ueda Teruhisa; Senba Hidenori; Todo Yasuhiko; Torisu Masamoto; Minami Hisaka; Onji Morikazu; Tanigawa Takeshi; Matsuura Bunzo; Hiasa Yoichi; Miyake Yoshihiro

来源：Neurourology and Urodynamics, 2016, 35(8): 1024-1027.

DOI：10.1002/nau.22875

• diabetes
• incontinence
• microvascular complications
• neuropathy

AimsDiabetes was significantly positively associated with urgency incontinence in several epidemiological studies. We examine the association between diabetic neuropathy, which we defined based on neuropathic symptoms, the absence of the Achilles reflex, and/or abnormal vibration perception, and urgency incontinence among Japanese patients with type 2 diabetes mellitus.
MethodsStudy subjects were 742 Japanese patients with type 2 diabetes mellitus, aged 19-70 years, who had undergone blood tests at our institutions. A self-administered questionnaire was used to collect information on the variables under study. Urgency incontinence was defined as present when a subject answered once a week or more to the question: Within one week, how often do you leak urine because you cannot defer the sudden desire to urinate ?. Diabetic neuropathy was diagnosed if the patients showed two or more of the following three characteristics: neuropathic symptoms, the absence of the Achilles reflex, and/or abnormal vibration perception. Adjustment was made for sex, age, body mass index, duration of type 2 diabetes mellitus, current smoking, hypertension, dyslipidemia, glycated hemoglobin, stroke, coronary artery disease, insulin therapy, diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy.
ResultsThe prevalence of urgency incontinence was 8.6%. Diabetic neuropathy was independently positively associated with urgency incontinence: the adjusted OR was 2.20 (95%CI: 1.16-4.36). Associations between diabetic retinopathy or nephropathy and the prevalence of urgency incontinence were not significant.
ConclusionsIn Japanese patients with type 2 diabetes mellitus, only diabetic neuropathy was independently positively associated with urgency incontinence. Neurourol. Urodynam. 35:1024-1027, 2016.

• 出版日期2016-11