Drug-induced lupus and autoimmune hepatitis secondary to infliximab for psoriasis

作者：Dang Lucy J^*; Lubel John S; Gunatheesan Shyamalar; Hosking Patrick; Su John

来源：Australasian Journal of Dermatology, 2014, 55(1): 75-79.

DOI：10.1111/ajd.12054

• adverse drug reaction
• dermatology
• gastroenterology
• hepatitis
• psoriasis

We describe a case of previously unreported autoimmune hepatitis and lupus-like syndrome induced by infliximab treatment for chronic plaque psoriasis. The condition resolved after withdrawal of infliximab, with the liver injury having been reversed and minimal periportal fibrosis. In a two-part discussion we review the current literature on the pharmacology of infliximab and provide recommendations for management of infliximab side effects.

• 出版日期2014-2