Anticonvulsant properties of Euterpe oleracea in mice

作者：Souza Monteiro Jose Rogerio; Hamoy Moises; Santana Coelho Danielle; Arrifano Gabriela P F; Paraense Ricardo S O; Costa Malaquias Allan; Mendonca Jackson R; da Silva Rafael F; Monteiro Wallena S C; Rogez Herve; de Oliveira Diogo L; do Nascimento Jose Luiz M; Crespo Lopez Maria Elena^*

来源：Neurochemistry International, 2015, 90: 20-27.

DOI：10.1016/j.neuint.2015.06.014

• Seizure
• Euterpe oleracea
• Anticonvulsant
• Oxidative stress
• EEG
• Amazon

Acai (Euterpe oleracea Mart.), a highly consumed fruit in Amazon, is from a common palm with remarkable antioxidant properties. Because oxidative stress and seizures are intimately linked, this study investigated the potential neuroprotective and anticonvulsant effects of commercial clarified acai juice (DO). EO did not alter spontaneous locomotor activity. Four doses of EO were sufficient to increase latencies to both first myoclonic jerk and first generalized tonic clonic seizure and significantly decrease the total duration of tonic-clonic seizures caused by pentylenetetrazol administration. Also, electrocortical alterations provoked by pentylenetetrazol were prevented, significantly decreasing amplitude of discharges and frequencies above 50 Hz. EO was also able to completely prevent lipid peroxidation in the cerebral cortex, showing a potent direct scavenging property. These results demonstrate for the first time that E. oleracea significantly protects against seizures and seizure-related oxidative stress, indicating an additional protection for humans who consume this fruit.

• 出版日期2015-11