Acne Treatment Based on Selective Photothermolysis of Sebaceous Follicles with Topically Delivered Light-Absorbing Gold Microparticles

作者：Paithankar Dilip Y^*; Sakamoto Fernanda H; Farinelli William A; Kositratna Garuna; Blomgren Richard D; Meyer Todd J; Faupel Linda J; Kauvar Arielle N B; Lloyd Jenifer R; Cheung Wang L; Owczarek Witold D; Suwalska Anna M; Kochanska Katarzyna B; Nawrocka Agnieszka K; Paluchowska Elwira B; Podolec Katarzyna M; Pirowska Magdalena M; Wojas Pelc Anna B; Anderson R Rox

来源：Journal of Investigative Dermatology, 2015, 135(7): 1727-1734.

DOI：10.1038/jid.2015.89

The pathophysiology of acne vulgaris depends on active sebaceous glands, implying that selective destruction of sebaceous glands could be an effective treatment. We hypothesized that light-absorbing microparticles could be delivered into sebaceous glands, enabling local injury by optical pulses. A suspension of topically applied gold-coated silica microparticles exhibiting plasmon resonance with strong absorption at 800 nm was delivered into human pre-auricular and swine sebaceous glands in vivo, using mechanical vibration. After exposure to 1050 J cm(-2), 30 milliseconds, 800 nm diode laser pulses, microscopy revealed preferential thermal injury to sebaceous follicles and glands, consistent with predictions from a computational model. Inflammation was mild; gold particles were not retained in swine skin 1 month after treatment, and uptake in other organs was negligible. Two independent prospective randomized controlled clinical trials were performed for treatment of moderate-to-severe facial acne, using unblinded and blinded assessments of disease severity. Each trial showed clinically and statistically significant improvement of inflammatory acne following three treatments given 1-2 weeks apart. In Trial 2, inflammatory lesions were significantly reduced at 12 weeks (P = 0.015) and 16 weeks (P = 0.04) compared with sham treatments. Optical microparticles enable selective photothermolysis of sebaceous glands. This appears to be a well-tolerated, effective treatment for acne vulgaris.

• 出版日期2015-7
• 单位河北医科大学