Antibacterial and antifouling properties of a polyurethane surface modified with perfluoroalkyl and silver nanoparticles

作者：Xu, Deqiu; Su, Yuling; Zhao, Lili; Meng, Fancui; Liu, Chang; Guan, Yayuan; Zhang, Jiya; Luo, Jianbin

来源：Journal of Biomedical Materials Research Part A, 2017, 105(2): 531-538.

DOI：10.1002/jbm.a.35929

• surface modification
• polyurethane
• polydopamine
• antibacterial
• antifouling

Inspired by mussel-adhesion phenomena in nature, a simple, mild surface modification process was elaborated to endow the polyurethane (PU) substrate with antibacterial/antifouling properties. In the present study, polydopamine was coated directly onto polyurethane surfaces. AgNO3 was then added and absorbed onto the surface by the active catechol and amine groups of the polydopamine coating. Meanwhile, the adsorbed Ag+ ions were reduced in situ into metallic silver nanoparticles by the bridge of the polydopamine coating which yielded a coating with good antimicrobial properties. Finally, 1H, 1H, 2H, 2H-perfluorodecanethiol (CF3(CF2)(7)CH2CH2SH, F-SH) was attached on the PDA coating via the Michael addition reaction. The hydrophobic F-SH layer above the antibacterial layer yielded a surface with excellent antifouling properties. Preliminary antibacterial assays indicate that the coated surfaces show enhanced antibacterial activity against Escherichia coli (Gram-negative bacteria) and Staphylococcus aureus (Gram-positive bacteria). Platelet adhesion was significantly reduced for the F-SH-coated PU film. These results suggest that the modified PU could be used as an antibacterial material for future biomedical applications.

• 出版日期2017-2
• 单位西南民族大学