A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones

作者：Radi Marco^*; Vallerini Gian Paolo; Petrelli Alessia; Vincetti Paolo; Costantino Gabriele

来源：Tetrahedron Letters, 2013, 54(50): 6905-6908.

DOI：10.1016/j.tetlet.2013.10.054

• Multicomponent reaction
• 2-Pyridones
• Microwave
• N1-substituted
• One-pot two-step
• Ring-fused

A fast, versatile and practical one-pot, two-step microwave-assisted protocol for the direct synthesis of N1-substituted 5,6-ring-fused 2-pyridones has been developed. The present method proved to be effective on a series of commercially available aldehydes, ketones and amines and could be profitably exploited in drug-discovery settings for the rapid identification of biologically relevant hit compounds.

• 出版日期2013-12-11