Toll-like receptors 4, 5, 6 and 7 are constitutively expressed in non-human primate retinal neurons

作者：Sauter Monica M; Kolb Aaron W; Brandt Curtis R^*

来源：Journal of Neuroimmunology, 2018, 322: 26-35.

DOI：10.1016/j.jneuroim.2018.06.007

• Retina
• Non-human primates
• Innate immunity
• Toll-like receptors
• Inflammation

The purpose of this study was to characterize cell-specific expression patterns of Toll-like receptors (TLR) in non-human primate (NHP) neural retina tissue. TLR 4, 5, 6, and 7 proteins were detected by immunblotting of macaque retina tissue lysates and quantitative PCR (qPCR) demonstrated TLRs 4-7 mRNA expression. Immunofluorescence (IF) microscopy detected TLRs 4-7 in multiple cell types in macaque neural retina including Muller, retinal ganglion cells (RGC), amacrine, and bipolar cells. These results demonstrate that TLRs 4-7 are constitutively expressed by neurons in the NHP retina raising the possibility that these cells could be involved in retinal innate inflammatory responses.

• 出版日期2018-9-15