ASSOCIATION OF EXPRESSION BETWEEN N-MYC GENE AND MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I GENE IN SURGICALLY RESECTED HUMAN NEUROBLASTOMA

作者：SUGIO K^*; NAKAGAWARA A; SASAZUKI T

来源：Cancer, 1991, 67(5): 1384-1388.

DOI：10.1002/1097-0142(19910301)67:5<1384::AID-CNCR2820670518>3.0.CO;2-7

Amplification of the N-myc gene in neuroblastoma correlates with advanced stage and poor prognosis. Association of the expression between N-myc and major histocompatibility complex (MHC) class I genes in 33 neuroblastomas obtained from Japanese children was investigated. Amplification of the N-myc gene was observed in two of five cases in Stage III, six of 11 cases in Stage IV, and one of five cases in Stage IV-S. In each case, the expression of N-myc gene was significantly increased. The expression was also increased in cases without amplification of the N-myc gene, the origin being from the suprarenal region. Expression of the MHC class I gene was significantly decreased in five of these nine with a high level of N-myc expression with amplification. These results suggest that the down-modulation of the MHC class I expression may be associated with the high level of expression and amplification of N-myc gene in the advanced stage of neuroblastoma.

• 出版日期1991-3-1