Absolute configuration of pterocidin, a potent inhibitor of tumor cell invasion from a marine-derived Streptomyces

作者：Igarashi Yasuhiro^*; Asano Daisuke; Furihata Kazuo; Oku Naoya; Miyanaga Satoshi; Sakurai Hiroaki; Saiki Ikuo

来源：Tetrahedron Letters, 2012, 53(6): 654-656.

DOI：10.1016/j.tetlet.2011.11.115

• Pterocidin
• Absolute configuration
• Invasion inhibitor
• Streptomyces

During the course of screening natural products for the inhibitors of tumor cell invasion, pterocidin, a linear polyketide with a delta-lactone terminus, was rediscovered from a Streptomyces strain of a marine sediment-origin. A series of J-based configuration analyses and NOESY analysis, coupled with chemical derivatization and chiral anisotropy analysis, established the absolute stereochemistry of five asymmetric centers in this compound.

• 出版日期2012-2-8