Nuclear dynamics of radiation-induced foci in euchromatin and heterochromatin

作者：Chiolo Irene^*; Tang Jonathan; Georgescu Walter; Costes Sylvain V

来源：Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 2013, 750(1-2): 56-66.

DOI：10.1016/j.mrfmmm.2013.08.001

• DSB response
• Chromatin dynamics
• Ionizing radiation
• Biomarker
• Modeling
• Cancer risk

Repair of double strand breaks (DSBs) is essential for cell survival and genome integrity. While much is known about the molecular mechanisms involved in DSB repair and checkpoint activation, the roles of nuclear dynamics of radiation-induced foci (RIF) in DNA repair are just beginning to emerge. Here, we summarize results from recent studies that point to distinct features of these dynamics in two different chromatin environments: heterochromatin and euchromatin. We also discuss how nuclear architecture and chromatin components might control these dynamics, and the need of novel quantification methods for a better description and interpretation of these phenomena. These studies are expected to provide new biomarkers for radiation risk and new strategies for cancer detection and treatment.

• 出版日期2013-10