A Review on the Effect of Traditional Chinese Medicine Against Anthracycline-Induced Cardiac Toxicity

作者：Yang, Xinyu; Liu, Nian; Li, Xinye; Yang, Yihan; Wang, Xiaofeng; Li, Linling; Jiang, Le; Gao, Yonghong; Tang, Hebin; Tang, Yong^*; Xing, Yanwei^*; Shang, Hongcai^*

来源：Frontiers in Pharmacology, 2018, 9: 444.

DOI：10.3389/fphar.2018.00444

• anthracyclines
• traditional Chinese medicine
• cardiac toxicity
• adverse effects
• antineoplastic

Anthracyclines are effective agents generally used to treat solid-tumor and hematologic malignancies. The use of anthracyclines for over 40 years has improved cancer survival statistics. Nevertheless, the clinical utility of anthracyclines is limited by its dose-dependent cardiotoxicity that adversely affects 10-30% of patients. Anthracycline-induced cardiotoxicity may be classified as acute/subacute or chronic/late toxicity and leads to devastating adverse effects resulting in poor quality of life, morbidity, and premature mortality. Traditional Chinese medicine has a history of over 2,000 years, involving both unique theories and substantial experience. Several studies have investigated the potential of natural products to decrease the cardiotoxic effects of chemotherapeutic agents on healthy cells, without negatively affecting their antineoplastic activity. This article discusses the mechanism of anthracycline-induced cardiotoxicity, and summarizes traditional Chinese medicine treatment for anthracycline-induced heart failure (HF), cardiac arrhythmia, cardiomyopathy, and myocardial ischemia in recent years, in order to provide a reference for the clinical prevention and treatment of cardiac toxicity.

• 出版日期2018-5-15
• 单位北京中医药大学; 首都医科大学附属北京安贞医院; 中南民族大学; 首都医科大学; 中国中医科学院广安门医院; 天津医科大学