Dasatinib is safe and effective in unselected chronic myeloid leukaemia elderly patients resistant/intolerant to imatinib

作者：Latagliata Roberto^*; Breccia Massimo; Castagnetti Fausto; Stagno Fabio; Luciano Luigiana; Gozzini Antonella; Ulisciani Stefano; Cavazzini Francesco; Annunziata Mario; Sora Federica; Rossi Antonella Russo; Pregno Patrizia; Montefusco Enrico; Abruzzese Elisabetta; Crisa Elena; Musto Pellegrino; Tiribelli Mario; Binotto Gianni; Occhini Ubaldo; Feo Costanzo; Vigneri Paolo; Santini Valeria; Fava Carmen; Rosti Giannantonio; Alimena Giuliana

来源：Leukemia Research, 2011, 35(9): 1164-1169.

DOI：10.1016/j.leukres.2011.05.015

• Chronic Myeloid Leukaemia
• Dasatinib
• Elderly
• Safety

To highlight dasatinib role in the elderly, 125 unselected patients with CP-CML aged >60 years resistant/intolerant to imatinib were retrospectively evaluated. Grade 3-4 haematological and extra-haematological toxicities were reported in 39 (31.2%) and 34 (27.2%) patients; grade 3-4 haematological toxicity was higher in patients with 140 mg starting dose (50.0% vs 19.6%, p = 0.001). Grade 3-4 pleuro-pericardial effusions occurred in 10 patients (8.0%). Dose reductions were more common in patients with 140 mg (88.4% vs 26.7%, p < 0.001). Of 122 evaluable patients, 72 (59.1%) had cytogenetic response [12 (9.8%) partial, 60 (49.3%) complete]. Overall, 38/60 patients in complete CyR also achieved a molecular response. Cumulative OS at 24 and 48 months were 93.1% (95% CI 88.4-97.8) and 84.2% (95% CI 74.6-93.7). Dasatinib, at the recommended dose of 100 mg/day, is effective and safe also in unselected elderly subjects.

• 出版日期2011-9