Microcirculatory Responses to Hyperoxia in Macular and Peripapillary Regions

作者：Xu, Huan; Deng, Guohua; Jiang, Chunhui^*; Kong, Xiangmei^*; Yu, Jian; Sun, Xinghuai

来源：Investigative Ophthalmology & Visual Science, 2016, 57(10): 4464-4468.

DOI：10.1167/iovs.16-19603

• optical coherence tomography
• angiography
• hyperoxia
• retinal microvasculature
• autoregulation

PURPOSE. To evaluate the hyperoxia response of the retinal vascular system in different parts of the fundus using optical coherence tomography (OCT) angiography. @@@ METHODS. Using an OCT angiography system and a split-spectrum amplitude decorrelation angiography (SSADA) algorithm, perfused vessel density at the macular and peripapillary regions was measured before and after breathing 80% oxygen in 10 healthy Chinese subjects. The repeatability of the hyperoxia response was also tested. @@@ RESULTS. Hyperoxia provocation caused a significant decrease in retinal perfused vessel density in both the macular and peripapillary areas. The para-and perifoveal area had a mean reduction of 13.66% and 15.17%, respectively; these reductions were significantly greater than in the peripapillary area (9.52%; parafovea versus peripapillary, P = 0.023; perifovea versus peripapillary, P = 0.006). The coefficients of variation (CV), intraclass correlations (ICC), and Bland-Altman plots suggested strong repeatability of the hyperoxia response. @@@ CONCLUSIONS. The optical coherence tomography system, in conjunction with the SSADA algorithm, recorded a significant reduction in retinal perfused vessel density after hyperoxia, and the reduction was greater in the macular area than in the peripapillary area.

• 出版日期2016-8
• 单位复旦大学