Aminolytic kinetic resolution of trans epoxides for the simultaneous production of chiral trans beta-amino alcohols in the presence of chiral Cr(III) salen complex using an ionic liquid as a green reaction media

作者：Kureshy Rukhsana I^*; Kumar Manish; Agrawal Santosh; Khan Noor ul H; Abdi Sayed H R; Bajaj Hari C

来源：Tetrahedron: Asymmetry , 2010, 21(4): 451-456.

DOI：10.1016/j.tetasy.2010.02.021

Chiral Cr(III) salen complex 1 having t-Bu substituents at 3,3' and 5,5'-positions was used as a catalyst for the highly enantioselective aminolytic kinetic resolution (AKR) of racemic trans epoxides with different anilines as nucleophile in the presence of different ionic liquids at rt. Excellent yields (>98%) of anti beta-aminoalcohols with high enantioselectivity (ee >99%) was achieved in 4 h when [bmim]PF(6) was used as the ionic liquid. The present ionic liquid mediated AKR process is recyclable (up to six cycles with no loss in performance) and is five times quicker than the homogeneous process utilizing conventional organic solvents.

• 出版日期2010-3-16
• 单位海洋化工研究院有限公司