Microwave-assisted click chemistry: synthesis of mono and bis-1,2,3-triazole acyclonucleoside analogues of Acyclovir via copper(I)-catalyzed cycloaddition

作者：Krim J; Sillahi B; Taourirte M^*; Rakib E M; Engels J W

来源：ARKIVOC, 2009, 142-152.

• 1,3-Dipolar cycloaddition
• 1,2,3 triazole
• 1,2,3-bis-triazoles
• acyclovir
• microwave

We report a short and efficient synthesis of 1,2,3-triazole and bis-1,2,3-triazoles acyclonucleoside analogues of Acycolovir. A series of novel 1,2,3-triazole acyclonucleosides linked to nucleobases were prepared via copper(I)-catalyzed 1,3-dipolar cycloaddition of N-9 propargylpurine, N-1-propargylpyrimidines or N-1-propargylindazoles with the azido-pseudosugar under Microwave-assisted synthesis followed by treatment with K(2)CO(3)/MeOH.

• 出版日期2009