Association of sVAP-1, sRAGE, and CML with lactation-induced insulin sensitivity in young non-diabetic healthy women

作者：Klenovicsova Kristina; Krivosikova Zora; Gajdos Martin; Sebekova Katarina^*

来源：Clinica Chimica Acta, 2011, 412(19-20): 1842-1847.

DOI：10.1016/j.cca.2011.06.019

• Lactation
• Insulin sensitivity
• sRAGE
• Adhesion molecules
• Advanced glycation
• sVAP-1

Background: In comparison with non-lactating women breast-feeding mothers display higher insulin sensitivity. Recent data suggest that advanced glycation end products, soluble receptor for advanced glycation end products (sRAGE) and soluble vascular adhesion protein-1 (sVAP-1) may play a role in insulin resistance even in healthy subjects. Aim: We studied whether breast-feeding induced insulin sensitivity associates with changes in concentrations of circulating sVAP-1, sRAGE and N(epsilon)-(carboxymethyl)lysine (CML) - chemically defined advanced glycation end product and RAGE ligand.
Methods: In 74 lactating non-diabetic mothers, 45 weaned non-diabetic mothers and 50 age-matched non-parous women insulin sensitivity was assessed using Quantitative insulin-sensitivity check index (QUICKI). sVAP-1, sRAGE and CML levels were determined.
Results: Lactating mothers were more insulin sensitive than their weaned and non-parous counterparts. Lactating mothers displayed the highest concentrations of sRAGE, and higher sVAP-1 levels if compared to weaned mothers. Both groups of mothers presented with lower CML levels than the non-parous women.
Conclusion: Lactation-induced insulin sensitivity is associated with higher sVAP-1 and a tendency towards higher sRAGE levels. Lactation-associated rise in sVAP-1 may promote effective glucose utilization in the mother. Lactation-induced insulin sensitivity vanishes shortly after weaning. In young healthy women CML levels are of no clinical relevance to insulin sensitivity.

• 出版日期2011-9-18