A novel fluorescent probe for imaging the process of HOCl oxidation and Cys/Hcy reduction in living cells

作者：Liu, Zhen; Li, Guoping^*; Wang, Yana; Li, Jiulong; Mi, Yang; Guo, Linna; Xu, Wenjian; Zou, Dapeng; Li, Tiesheng^*; Wu, Yangjie^*

来源：RSC Advances, 2018, 8(17): 9519-9523.

DOI：10.1039/c7ra13419c

• HYPOCHLOROUS ACID DETECTION
• THIOLS REDUCING REPAIR
• LIVE CELLS
• GLUTATHIONE-PEROXIDASE
• REACTIVE OXYGEN
• RAPID DETECTION
• REDOX CYCLES
• MYELOPEROXIDASE ACTIVITY
• SELECTIVE DETECTION
• LUMINESCENT PROBES

A new on-off-on fluorescent probe, CMOS, based on coumarin was developed to detect the process of hypochlorous acid (HOCl) oxidative stress and cysteine/homocysteine (Cys/Hcy) reduction. The probe exhibited a fast response, good sensitivity and selectivity. Moreover, it was applied for monitoring the redox process in living cells.

• 出版日期2018
• 单位郑州大学