Ultrasound Assisted 1,4-diazabicyclo[2.2.2] Octaniumdiacetate Multicomponent Synthesis of Benzodiazepines: A Novel, Highly Efficient and Green Protocol

作者：Sarhandi Shahriar; Fekri Leila Zare^*; Vessally Esmail

来源：Acta Chimica Slovenica, 2018, 65(1): 246-252.

DOI：10.17344/acsi.2017.3723

• Dimedone
• benzodiazepines
• ionic liquid
• green chemistry

A simple and efficient method is presented for the synthesis of benzodiazepines through the multicomponent reaction of o-phenylenediamine, various aldehydes and 5,5-dimethylcyclohexane-1,3-dione (dimedone) in the presence of the acidic bis ionic liquid 1,4-diazabicyclo[2.2.2] octanium diacetate under ultrasound irradiation. The ionic liquid used is recoverable and reusable. This procedure is simple and environmentally friendly, and offers easy work-up, mild conditions and excellent yield in a short reaction time. All of the synthesized compounds were characterized by IR, H-1 NMR, mass spectrometry and elemental analysis.

• 出版日期2018