A new lignan with hypoglycemic activity from Tadehagi triquetrum

作者：Wu, Jiani; Zhang, Cai yun; Zhang, Tingting; Zhao, Dan; An, Ni; Li, Youbin; Zhu, Nailiang; Wang, Shuai; Chen, Feng^*; Zhang, Xiaopo

来源：Natural Product Research, 2015, 29(18): 1723-1727.

DOI：10.1080/14786419.2014.1003136

• Tadehagi triquetrum
• tadehaginosin
• hypoglycemic effects

A new lignan named tadehaginosin, together with a known compound 3,4-dihydro-4-(4-hydroxyphenyl)-5,7-dihydroxycoumarin, was isolated from the aerial part of Tadehagi triquetrum. The new structure was determined by various spectroscopic techniques (H-1 and C-13 APT, HSQC, HMBC, H-1-(HCOSY)-H-1, NOESY and HR-ESI-MS). The two isolates were evaluated for their hypoglycemic effects in vitro. Biological investigation showed that both of them possessed the capability to increase glucose consumption by HepG2 cells.

• 出版日期2015-9-17
• 单位海南医学院; 中国医学科学院北京协和医院; 哈尔滨商业大学; 河北医科大学; 北京协和医学院