Multicomponent Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Novel Spiro-Tethered Pyrazolo[3,4-b]quinoline Hybrid Heterocycles

作者：Sumesh Remani Vasudevan; Muthu Muthumani; Almansour Abdulrahman I; Kumar Raju Suresh; Arumugam Natarajan; Athimoolam S; Prabha E Arockia Jeya Yasmi; Kumar Raju Ranjith

来源：ACS Combinatorial Science, 2016, 18(5): 262-270.

DOI：10.1021/acscombsci.6b00003

• 1,3-dipolar cycloaddition
• azomethine ylide
• alpha-amino acid
• isatin
• pyrazolo[3,4-b]quinoline
• spiro-oxindole
• spiro-pyrrolidine

The stereoselective syntheses of a library of novel spiro-tethered pyrazolo[3,4-b]quinoline pyrrolidine/pyrrolothiazole/indolizine oxindole/acenaphthene hybrid heterocycles have been achieved through the 1,3-dipolar cycloaddition of azomethine ylides generated in situ from a amino acids and 1,2-diketones to dipolarophiles derived from pyrazolo [3,4-b]quinoline derivatives.

• 出版日期2016-5